What are the production methods of active pharmaceutical ingredients

The production process of chemically synthesized active pharmaceutical ingredients refers to the use of chemical raw materials to synthesize compounds with medicinal properties through chemical reactions under specific conditions, and then go through processes such as crystallization and drying to meet various quality standards for drugs. This process requires precise control of reaction conditions to ensure the purity and stability of the product.

The production process of fermented raw materials is another important way in the production of raw materials, especially in the production of antibiotic raw materials such as penicillin and cephalosporins. These types of active pharmaceutical ingredients are usually prepared through a combination of microbial fermentation and chemical synthesis. The basic substances are first produced through fermentation, and then modified and purified through chemical synthesis.

The production process of sterile raw materials mainly targets raw materials that are sensitive to high temperature, high pressure, and radiation. Aseptic raw materials are divided into two types: final sterilization and non final sterilization. However, sterile raw materials with final sterilization are less commonly used because they need to avoid high temperatures and pressures during production to maintain their biological activity.

The production process of animal and plant extracted raw materials utilizes natural animals and plants to extract natural compounds that are of great significance for disease treatment. This method is an important way to obtain target compounds and is also one of the main ways to produce active pharmaceutical ingredients. By extracting active ingredients from animals and plants, complex compounds that cannot be obtained through chemical synthesis can be obtained for the preparation of drugs.