Requirements for production equipment for pharmaceutical intermediates

The requirements for equipment in the production of pharmaceutical intermediates mainly include material selection, structural design, safety performance, and maintenance

Material and Structure
Reactor: commonly made of glass, stainless steel, enamel glass, and engineering plastic materials, with a capacity ranging from 50L to 500L. It is recommended to use a slim and non-standard design, with mixing forms including anchor type, impeller type, and frame type. A baffle can be added to enhance the effect.  ‌
Condenser: Materials include glass, stainless steel, enamel glass, graphite, etc., and pressure adaptability, corrosiveness, and heat transfer efficiency need to be considered.  ‌
Filtration system: A targeted membrane separation filtration system is required to extend the service life of the equipment.  ‌

Security and functionality
Safety protection: The equipment should have dust-proof, explosion-proof, anti-static and other protective functions, and be equipped with emergency braking devices.  ‌
Online monitoring: The equipment is required to have an automatic analysis and processing system to achieve process linkage control.  ‌
Cleaning function: Priority is given to using a CIP system to reduce the risk of cross contamination.  

Maintenance and after-sales service
It is necessary to choose products from enterprises with good brand reputation and comprehensive after-sales service to avoid production being affected by accessory quality or maintenance issues.  ‌
Regularly check the thickness and material of steel plates to avoid equipment deformation or corrosion caused by cutting corners.  ‌

Regulatory requirements
Compliant with GMP standards, the equipment needs to have purification and cleaning functions, the structure should reduce dead corners and material retention, and parts in contact with drugs need to be polished.